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Associate Director/Director, Translational Biology

 Xencor Inc. is an innovative biotechnology company located in the Los Angeles area (near Pasadena) and in San Diego.  We have a very deep drug development pipeline including six programs currently in clinical testing with two more expected to start clinical testing by 1H2019 and have an excellent opportunity for an Associate Director/Director of Translational Biology to join our team.  We use our pioneering XmAb technology to develop better biotherapeutics - antibodies that target new biological mechanisms and have the potential to be more potent, safer and longer lasting - with the goal of improving patient outcomes and quality of life.  In addition to generating a pipeline of novel drug candidates, with twelve in clinical testing by Xencor or our partners, our XmAb technology has enabled multiple collaborations with leading biopharmaceutical companies including Novartis, Amgen,  Morphosys, CSL, Alexion and Boehringer Ingelheim.  Our employees are the most important factor in our success and we have assembled a highly talented group from diverse backgrounds and disciplines to execute our business plan and shape our future. Xencor employees value new ideas and flexibility and demand from each other scientific rigor, a passion for innovation, and a willingness to take risks.  We seek an Associate Director/Director of Translational Biology, with title commensurate with experience to drive the biomarker analysis in clinical biospecimens in clinical studies using Xencor bispecific antibodies (T cell engagers, checkpoints, targeted and engineered cytokines). Job Duties include: The Director/Associate Director, Translational Biology, acts as an independent scientist responsible for coordinating the analysis of genomics/transcriptomics/immunobiological data for preclinical studies and clinical studies. This person interacts with all members of the Translational Biology, Biometrics, Pre-Clinical and Clinical Development teams, and is accountable for the oversight and quality of analysis of immunobiological data (flow cytometry/multiplex immunofluorescence/cytokines) for clinical samples and genomics/transcriptomics data for pre-clinical science and clinical samples. Responsibilities may include some or all of the following: oPlan, implement and manage biomarker projects with outside laboratories oChampion analysis of genomics/transcriptomics for tumor biopsies and peripheral blood samples oParticipate with preclinical projects that require genomic/transcriptomic analysis of cultured cells or tissues/blood from animal models oLead contact on high dimensional data sets, e.g., transcriptomics of clinical trials  oEnsure that clinical biomarker data is scientifically rigorous and supports clinical development oManage a shared biostatistician with expertise in programming for high dimensional data sets, e.g., transcriptomics/genomics data Present pre-clinical data and the relevant literature at internal meetings  oEffectively manage projects as part of a multidisciplinary team oContribute to publications and presentations oRepresent supported projects at scientific conferences oLeads interactions with investigators and cooperative groups oAttends 3-4 scientific meeting or off-site meetings per year oOther duties as assigned oDeep understanding of complex cellular signaling pathways  oData review, writing and interpretation oAbility to work effectively with a cross-functional study team oAbility to manage multiple (3-5) projects simultaneously, set and meet deadlines oAbility to analyze complex flow cytometric data, transcriptomics (including Nanostring and RNAseq) and multiplex immunofluorescence.  oExcellent oral and written communication skills Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that ae required of the employee for this job.  Duties, responsibilities and activities may change at any time with or without notice. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice. Qualifications/Requirements: oAdvanced Clinical/Science Degree (e.g. PharmD, PhD, Postdoctoral) oExperience in pre-clinical/translational drug discovery, demonstrated strong achievements in academic and industry settings oMinimum 5 years pre-clinical development experience in the pharmaceutical or biotechnology industry, 2 years may be sufficient for candidates with translational postdoctoral experience oKnowledge of international regulations pertinent to current clinical development (eg ICH, FDA, EMA) oAbility to analyze complex flow cytometric data (FloJo), transcriptomics (including Nanostring and RNAseq) and multiplex immunofluorescence oUnderstanding of immunobiology and eagerness to work with clinical immunoncology data oHighly advanced oral, writing and presentations skills oOrganized and able to set/meet deadlines.
Salary Range: NA
Minimum Qualification
5 - 7 years

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